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Warfarin and Ibuprofen - Deadly or Just a Bad Idea?

Sunday, April 2nd, 2006
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I was told it could be deadly to take Ibuprofen while taking coumadin. I
understand ibuprofen is a blood thinner as is coumadin but is it truly
deadly or just a bad idea?

Dr. Joshua’s Answer:


It’s generally a bad idea and it might even be deadly. The lowdown: continued use of NSAIDs such as ibuprofen increases the risk of gastrointestinal bleeding, and if a bleed occurs, warfarin will make it much worse.

Gabb GM.
Fatal outcome of interaction between warfarin and a non-steroidal anti-inflammatory drug.
Med J Aust. 1996 Jun 3;164(11):700-1


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