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High uric acid in blood, low uric acid in urine

Sunday, April 2nd, 2006
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Two years ago I had kidney stones in my left kidney. But I have not had another attack since. Nevertheless, Two weeks ago I went to see my family doctor for a check up. She tested my urine with the stick and it showed that I had blood in the urine. She ordered a blood test and 24hr urine test. The blood test results showed that my uric acid is high. But the urine test does not show anything wrong. My doctor could not explain to me why the uric acid is not in my urine as well. I decided not to take any medication to lower my uric acid but try to control it with a diet. I visited a dietitian and to my surprise I am not eating too bad. I don’t eat too much meat or the other food that I have to avoid.
My concern is that my doctor could not explain the test results and I do not want to take medication for my whole life and besides it could affect my kidneys, liver, etc.

Dr. Joshua’s Answer:


High uric acid in blood can cause gout. High uric acid in urine can cause kidney stones. However, kidney stones are more often caused by calcium phosphate or calcium oxalate, less frequently by uric acid. A high uric acid level in blood combined with a low uric acid in urine may suggest that the kidneys are not secreting uric acid normally. Further kidney function tests may be needed.

Factors that increase blood uric acid include alcohol use, obesity, high protein diet, diuretics, some other medications, and various diseases.

I’m happy that you’ve had your diet evaluated. Discuss with your physician a schedule for checking the uric acid levels again, and possibly other kidney function tests if needed, lab tests such as creatinine and creatinine clearance, and possibly kidney sonogram.


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